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ea0056s5.3 | The role of sperm epigenome in fertility and inheritance | ECE2018

Mechanisms of epigenetic inheritance through sperm: lessons we have learnt from model organisms

Vavouri Tanya

Our lifestyle habits and environmental exposures are typically considered to affect only our health (with the exception of pregnant mothers). Nevertheless, there is epidemiological evidence from human studies that adverse health consequences can also be observed in offspring and grand offspring (e.g. Roseboom et al., Molecular and Cellular Endocrinology, 2001). The mechanisms of trans- or inter-generational epigenetic inheritance are currently not known. We, and other...